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KMID : 0613820090190040514
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Journal of Life Science
2009 Volume.19 No. 4 p.514 ~ p.519
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Effects of Luteolin on IL-1β-Induced MCP1 Protein Expression
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Lim Jun-Hee
Kwon Taeg-Kyu
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Abstract
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Monocyte chemoattractant protein 1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined interleukin-1β (IL-1β) induced MCP1 expressions via activation of transcription factor NF-κB in primary human aorta smooth muscle cells. We determined the effect of several anti-inflammatory agents on IL-1β-induced MCP1 expression. The pretreatment of luteolin significantly suppressed IL-1β-induced MCP1 expressions through blocking activation and translocation of NF-κB to the nucleus.
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KEYWORD
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Luteolin, monocyte chemoattractant protein 1(MCP1), interleukin-1β(IL-1β), nuclear factor-κB(NF-κB)
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